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1

MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

Clarissa E. Vergunst, Danielle M. Gerlag, Lisa von Moltke, Michael Karol, Tim Wyant, Xuedong Chi, Ellen Matzkin, Timothy Leach, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 169 KB

english, 2009

2

Effect of icodextrin on volume status, blood pressure and echocardiographic parameters: A randomized study

Konings, Constantijn JAM, Kooman, Jeroen P, Schonck, Marc, Gladziwa, Ulrich, Wirtz, Joris, Van Den Wall Bake, A Warmold, Gerlag, Paul G, Hoorntje, Steven J, Wolters, Johannes, Van Der Sande, Frank M,

Journal:

Kidney International

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

3

Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering

Hähnlein, Janine S., Ramwadhdoebe, Tamara H., Semmelink, Johanna F., Choi, Ivy Y., Berger, Ferco H., Maas, Mario, Gerlag, Danielle M., Tak, Paul P., Geijtenbeek, Teunis B. H., van Baarsen, Lisa G. M.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.49 MB

english, 2018

4

Monocyte Scintigraphy in Rheumatoid Arthritis: The Dynamics of Monocyte Migration in Immune-Mediated Inflammatory Disease

Thurlings, Rogier M., Wijbrandts, Carla A., Bennink, Roelof J., Dohmen, Serge E., Voermans, Carlijn, Wouters, Diana, Izmailova, Elena S., Gerlag, Danielle M., van Eck-Smit, Berthe L. F., Tak, Paul P.,

Journal:

Year:

2009

Language:

english

File:

PDF, 367 KB

english, 2009

5

Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman’s Disease

Musters, Anne, Assaf, Amira, Gerlag, Danielle M., Tak, Paul P., Tas, Sander W.

Journal:

Frontiers in Immunology

Year:

2015

Language:

english

File:

PDF, 426 KB

english, 2015

6

Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation

Paul P. Tak, Danielle M. Gerlag, Karl R. Aupperle, Deliana A. Van De Geest, Marieke Overbeek, Brydon L. Bennett, David L. Boyle, Anthony M. Manning, Gary S. Firestein

Journal:

Arthritis & Rheumatism

Year:

2001

Language:

english

File:

PDF, 1.97 MB

english, 2001

7

Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis

Danielle M. Gerlag, Jasper J. Haringman, Tom J. M. Smeets, A. H. Zwinderman, Maarten C. Kraan, Peter J. Laud, Shethah Morgan, Anthony F. P. Nash, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

8

Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

Koen Vos, Rogier M. Thurlings, Carla A. Wijbrandts, Dirkjan van Schaardenburg, Daniëlle M. Gerlag, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2007

Language:

english

File:

PDF, 202 KB

english, 2007

9

Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker

Carla A. Wijbrandts, Clarissa E. Vergunst, Jasper J. Haringman, Danielle M. Gerlag, Tom J. M. Smeets, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

10

Modulation of CCR2 in rheumatoid arthritis: A double-blind, randomized, placebo-controlled clinical trial

Clarissa E. Vergunst, Daniëlle M. Gerlag, Luba Lopatinskaya, L. Klareskog, M. D. Smith, F. van den Bosch, Huib J. Dinant, Yih Lee, Timothy Wyant, Eric W. Jacobson, Dominique Baeten, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008

11

Tumor necrosis factor α drives cadherin 11 expression in rheumatoid inflammation

Bernard Vandooren, Tineke Cantaert, Mariëtte Ter Borg, Troy Noordenbos, Rodger Kuhlman, Daniëlle Gerlag, Tim Bongartz, Kris Reedquist, Paul P. Tak, Dominique Baeten

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 323 KB

english, 2008

12

Disease activity–guided rituximab therapy in rheumatoid arthritis: The effects of re-treatment in initial nonresponders versus initial responders

Rogier M. Thurlings, Koen Vos, Daniëlle M. Gerlag, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 189 KB

english, 2008

13

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study

Ruth Klaasen, Rogier M. Thurlings, Carla A. Wijbrandts, Arno W. van Kuijk, Dominique Baeten, Danielle M. Gerlag, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 89 KB

english, 2009

14

Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

Daniëlle M. Gerlag, Sally Hollis, Mark Layton, Jiří Vencovský, Zoltán Szekanecz, Martin Braddock, Paul P. Tak, ESCAPE Study Group

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 152 KB

english, 2010

15

Body mass index and clinical response to infliximab in rheumatoid arthritis

Ruth Klaasen, Carla A. Wijbrandts, Danielle M. Gerlag, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 93 KB

english, 2011

16

Reply

Ruth Klaasen, Carla A. Wijbrandts, Danielle M. Gerlag, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 33 KB

english, 2011

17

Response to rituximab in patients with rheumatoid arthritis in different compartments of the immune system

Maria J. H. Boumans, Rogier M. Thurlings, Danielle M. Gerlag, Koen Vos, Paul P. Tak

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 220 KB

english, 2011

18

Preventing dialysis hypotension: A comparison of usual protective maneuvers

Kooman, Jeroen P, Moret, Karin, van der Sande, Frank M, Gerlag, Paul G G, van den Wall Bake, A Warmold, Leunissen, Karel M L

Journal:

Kidney International

Year:

2001

Language:

english

File:

PDF, 46 KB

english, 2001

19

Rejection of skin grafts in the nude mouse

KOENE, ROBERT A. P., GERLAG, PAUL G. G., JANSEN, JAN J., HAGEMANN, JACQ. F. H., WIJDEVELD, PAUL G. A. B.

Journal:

Year:

1974

File:

PDF, 356 KB

1974

20

Differences between anti-myeloperoxidase- and anti-proteinase 3-associated renal disease

Franssen, Casper FM, Gans, Reinold OB, Arends, Bertjan, Hageluken, Conny, ter Wee, Piet M, Gerlag, Paul GG, Hoorntje, Steven J

Journal:

Kidney International

Year:

1995

Language:

english

File:

PDF, 723 KB

english, 1995

21

Brief Report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

Sarah Krausz, Maria J. H. Boumans, Danielle M. Gerlag, Joelle Lufkin, Arno W. R. van Kuijk, Alian Bakker, Maarten de Boer, Beatrijs M. Lodde, Kris A. Reedquist, Eric W. Jacobson, Michael O'Meara, Paul

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 361 KB

english, 2012

22

Synovial biopsy

Danielle Gerlag, Paul P. Tak

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

23

Novel approaches for the treatment of rheumatoid arthritis: lessons from the evaluation of synovial biomarkers in clinical trials

Daniëlle M. Gerlag, Paul P. Tak

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

24

How to perform and analyse synovial biopsies

Daniëlle M. Gerlag, Paul P. Tak

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2009

Language:

english

File:

PDF, 580 KB

english, 2009

25

Diuretic efficacy of high dose furosemide in severe heart failure: Bolus injection versus continuous infusion

Tom P.J. Dormans, Joseph J.M. van Meyel, Paul G.G. Gerlag, Yuen Tan, Frans G.M. Russel, Paul Smits

Journal:

Journal of the American College of Cardiology

Year:

1996

Language:

english

File:

PDF, 691 KB

english, 1996

26

Combination Diuretic Therapy in Severe Congestive Heart Failure

Dr Tom P. J. Dormans, Paul G. G. Gerlag, Frans G. M. Russel, P. Smits

Journal:

Year:

1998

Language:

english

File:

PDF, 236 KB

english, 1998

27

How to perform and analyse synovial biopsies

Gerlag, Daniëlle M., Tak, Paul P.

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

28

How useful are synovial biopsies for the diagnosis of rheumatic diseases?

Gerlag, Danielle M, Tak, Paul P

Journal:

Nature Clinical Practice Rheumatology

Year:

2007

Language:

english

File:

PDF, 84 KB

english, 2007

29

Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature

Danielle M Gerlag, Eric Borges, Paul P Tak, H Michael Ellerby…

Journal:

Arthritis Research & Therapy

Year:

2001

Language:

english

File:

PDF, 468 KB

english, 2001

30

Reply

Bruyninckx, Cornelis M.A., Bender, Mart H.M., Gerlag, Paul G.G.

Journal:

Journal of Vascular Surgery

Year:

1995

Language:

english

File:

PDF, 1.44 MB

english, 1995

31

Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation

Gerlag, Paul G.G., Lobatto, Sacha, Driessen, Willem M.M., Deckers, Pius F.L., Van Hooff, Johannes P., Schröder, Ed, Assmann, Karel M., Van Haelst, Urbain J.G.

Journal:

Journal of Hepatology

Year:

1985

Language:

english

File:

PDF, 2.10 MB

english, 1985

32

The brachiocephalic elbow fistula: A useful alternative angioaccess for permanent hemodialysis

Bender, Mart H.M., Bruyninckx, Cornelis M.A., Gerlag, Paul G.G.

Journal:

Journal of Vascular Surgery

Year:

1994

Language:

english

File:

PDF, 435 KB

english, 1994

33

Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine

Yoshida, Ken, Korchynskyi, Olexandr, Tak, Paul P., Isozaki, Takeo, Ruth, Jeffrey H., Campbell, Phillip L., Baeten, Dominique L., Gerlag, Danielle M., Amin, M. Asif, Koch, Alisa E.

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

34

Absorption of High Dose Furosemide (Frusemide) in Congestive Heart Failure

Dr Joseph J. M. Van Meyel,Paul G. G. Gerlag,Paul Smits…

Journal:

Clinical Pharmacokinetics

Year:

1992

Language:

english

File:

PDF, 1.64 MB

english, 1992

35

Urine flow cytometry and detection of glomerular hematuria

Scharnhorst, Volkher, Gerlag, Paul G.G., Nanlohy Manuhutu, Miel L., van der Graaf, Fedde

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2006

Language:

english

File:

PDF, 93 KB

english, 2006

36

High-Dose Furosemide in the Treatment of Refractory Congestive Heart Failure

Gerlag, Paul G. G.

Journal:

Archives of Internal Medicine

Year:

1988

Language:

english

File:

PDF, 692 KB

english, 1988

37

Local Synovial Engagement of Angiogenic TIE-2 Is Associated With the Development of Persistent Erosive Rheumatoid Arthritis in Patients With Early Arthritis

van de Sande, Marleen G. H., de Launay, Daphne, de Hair, Maria J. H., García, Samuel, van de Sande, Gijs P. M., Wijbrandts, Carla A., Gerlag, Danielle M., Reedquist, Kris A., Tak, Paul P.

Journal:

Arthritis & Rheumatism

Year:

2013

Language:

english

File:

PDF, 756 KB

english, 2013

38

Intra-articular etanercept treatment in inflammatory arthritis: A randomized double-blind placebo-controlled proof of mechanism clinical trial validating TNF as a potential therapeutic target for local treatment

Aalbers, Caroline, Gerlag, Danielle, Vos, Koen, Vervoordeldonk, Margriet, Landewé, Robert, Tak, Paul Peter

Journal:

Joint Bone Spine

Year:

2015

Language:

english

File:

PDF, 992 KB

english, 2015

39

RA: from risk factors and pathogenesis to prevention

Gerlag, Danielle M., Norris, Jill M., Tak, Paul P.

Journal:

Year:

2015

Language:

english

File:

PDF, 103 KB

english, 2015

40

Acute and Long-Term Effects of Therapy with High-Dose Furosemide in Chronic Hemodialysis Patients

van Olden, Rudolf W., van Meyel, Joseph J.M., Gerlag, Paul G.G.

Journal:

American Journal of Nephrology

Year:

1992

File:

PDF, 1.23 MB

1992

41

Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy

Ramos, Maria I., Teunissen, Marcel B. M., Helder, Boy, Aarrass, Saida, de Hair, Maria J. H., van Kuijk, Arno W., Gerlag, Danielle M., Tak, Paul P., Lebre, Maria C.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

42

HYPERACUTE REJECTION OF SKIN ALLOGRAFTS IN THE MOUSE

GERLAG, PAUL G. G., KOENE, ROBERT A. P., HAGEMANN, JACQUELINE F. H. M., WIJDEVELD, PAUL G. A. B.

Journal:

Transplantation Journal

Year:

1975

File:

PDF, 421 KB

1975

43

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Pharmacokinetic Modeling: Initial Experience in Patients With Early Arthritis

Maijer, Karen I., van der Leij, Christiaan, de Hair, Maria J. H., Tas, Sander W., Maas, Mario, Gerlag, Daniëlle M., Tak, Paul P., Lavini, Cristina

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 281 KB

english, 2016

44

Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients

Maijer, Karen I., Gerlag, Daniëlle M., Tak, Paul P.

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 55 KB

english, 2015

45

Diazoxide infusion in severe hypertension and hypertensive crisis

Thien, Theo A., Huysmans, Frans T. M., Gerlag, Paul G. G., Koene, Robert A. P., Wijdeveld, Paul G. A. B.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1979

Language:

english

File:

PDF, 448 KB

english, 1979

46

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

Ai, Rizi, Whitaker, John W., Boyle, David L., Tak, Paul Peter, Gerlag, Danielle M., Wang, Wei, Firestein, Gary S.

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 190 KB

english, 2015

47

A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis

Collins, Emily S., Butt, Aisha Q., Gibson, David S., Dunn, Michael J., Fearon, Ursula, van Kuijk, Arno W., Gerlag, Danielle M., Pontifex, Eliza, Veale, Douglas J., Tak, Paul P., FitzGerald, Oliver, Pe

Journal:

PROTEOMICS - Clinical Applications

Year:

2016

Language:

english

File:

PDF, 675 KB

english, 2016

48

Injection intra-articulaire d’étanercept dans le traitement local des rhumatismes inflammatoires : étude pilote contrôlée avec étude de mécanisme

Aalbers, Caroline, Gerlag, Danielle, Vos, Koen, Vervoordeldonk, Margriet, Landewé, Robert, Tak, Paul Peter

Journal:

Revue du Rhumatisme

Year:

2016

Language:

french

File:

PDF, 958 KB

french, 2016

49

Altered Innate Lymphoid Cells subsets in human lymph node biopsies during the at risk and earliest phase of rheumatoid arthritis

Rodríguez-Carrio, Javier, Hähnlein, Janine S., Ramwadhdoebe, Tamara H., Semmelink, Johanna F., Choi, Ivy Y., van Lienden, Krijn P., Maas, Mario, Gerlag, Danielle M., Tak, Paul P., Geijtenbeek, Teunis

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 910 KB

english, 2016

50

The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation

Tang, Man Wai, Reedquist, Kris A., Garcia, Samuel, Fernandez, Bea Malvar, Codullo, Veronica, Vieira-Sousa, Elsa, Goffin, Vincent, Reuwer, Anne Q., Twickler, Marcel T., Gerlag, Daniëlle M., Tak, Paul-P

Journal:

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016